Blood Bioactive Sphingolipids and Activity of Acid Sphingomyelinase in Patients with Multivessel Coronary Artery Disease
نویسندگان
چکیده
Aim: Ceramide is claimed to participate in development of atherosclerosis. Another bioactive sphingolipid, namely sphingosine-1-phosphate has anti-atherogenic properties. The aim of the present study was to examine the level of ceramide, sphingosine-1-phosphate, sphinganine-1-phosphate, sphingosine and sphinganine in plasma, erythrocytes and platelets of patients with multivessel coronary artery disease.
منابع مشابه
Age‐related remodeling of small arteries is accompanied by increased sphingomyelinase activity and accumulation of long‐chain ceramides
The structure and function of large arteries alters with age leading to increased risk of cardiovascular disease. Age-related large artery remodeling and arteriosclerosis is associated with increased collagen deposition, inflammation, and endothelial dysfunction. Bioactive sphingolipids are known to regulate these processes, and are also involved in aging and cellular senescence. However, less ...
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